Parabens
Parabens are widely used as preservatives by cosmetic and pharmaceutical
industries. They can be found in shampoos, commercial moisturizers, shaving gels, personal lubricants, spray
tanning solution, makeup and toothpaste.
They are also used as food
additives.
Toxicity
Breast
cancer
Average
levels of 20 nanograms/gram of parabens have been detected in a small sample of
20 breast tumors. These findings, along with the demonstrated ability of some
parabens to partially mimic estrogen, a hormone known to play a role in the
development of breast cancers, have led some people to conclude that the
presence of parabens may be associated with the occurrence of breast cancer,
though scientists say no link can be determined from current studies and that
more research called for.
The
lead researcher of the UK study, molecular biologist Philippa Darbre, reported
that the ester-bearing form of the parabens found in the tumors indicate that
they came from something applied to the skin, such as an underarm deodorant,
cream or body spray, and stated that the results helped to explain why up to
60% of all breast tumors are found in just one-fifth of the breast - the
upper-outer quadrant, nearest the underarm (though this is controversial).
"From this research it is not possible to say whether parabens actually
caused these tumors, but they may certainly be associated with the overall rise
in breast cancer cases. Given that breast cancer is a large killer of women and
a very high percentage of young women use underarm deodorants, I think we
should be carrying out properly funded, further investigations into parabens and
where they are found in the body," says Philip Harvey, an editor of the Journal
of Applied Toxicology, which published the research. A 2004 study at Northwestern
University found that an earlier age of breast cancer diagnosis related to
more frequent use of antiperspirants/deodorants and underarm shaving. "I
personally feel there is a very strong correlation between the underarm hygiene
habits and breast cancer," said immunologist Dr. Kris McGrath, the author
of the study.
This
research has fueled a popular belief that the parabens in underarm deodorants
and other cosmetics can migrate into breast tissue and contribute to the
development of tumors.
However,
no direct evidence of a causal link between parabens and cancer has been shown.
A 2005 review of the data available at that time concluded "it is
biologically implausible that parabens could increase the risk of any
estrogen-mediated endpoint, including effects on the male reproductive tract or
breast cancer" and that "worst-case daily exposure to parabens would
present substantially less risk relative to exposure to naturally occurring endocrine
active chemicals in the diet such as the phytoestrogen daidzein.
The American Cancer Society also concluded that there was
insufficient scientific evidence to support a claim that use of cosmetics such
as antiperspirants increase an individual's risk of developing breast cancer,
but went on to state that "larger studies are needed to find out what
effect, if any, parabens might have on breast cancer risk.
Sun exposure
Studies indicate that methylparaben applied on the skin
may react with UVB leading
to increased skin aging and DNA damage.
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